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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage
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Published on: February 15, 2020

Oxidative stress in primary open-angle glaucoma.

Carl Erb1, Melanie Heinke

  • 1Schlosspark-Klinik, Department of Ophthalmology, Berlin, Germany. Carl.erb@schlosspark-klinik.de

Frontiers in Bioscience (Elite Edition)
|May 31, 2011
PubMed
Summary
This summary is machine-generated.

Oxidative stress plays a key role in glaucoma pathogenesis, affecting mitochondria and reducing antioxidative capacity. Targeting oxidative stress may offer new therapeutic strategies for glaucoma patients.

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Area of Science:

  • Ophthalmology
  • Cell Biology
  • Pathophysiology

Background:

  • Glaucoma is a leading cause of blindness globally.
  • Known risk factors include intraocular pressure, myopia, age, genetics, vascular issues, and smoking.
  • The precise mechanisms of glaucomatous optic neuropathy remain unclear.

Purpose of the Study:

  • To investigate the role of oxidative stress in glaucoma pathogenesis.
  • To highlight the importance of oxidative stress in therapeutic strategies for glaucoma.

Main Methods:

  • Analysis of mitochondrial abnormalities in glaucoma.
  • Assessment of antioxidative capacity reduction.
  • Evaluation of oxidative stress markers in anterior and posterior segments of glaucoma patients' eyes.

Main Results:

  • Mitochondria exhibit abnormal DNA in glaucoma.
  • Reduced antioxidative capacity is observed.
  • Elevated oxidative stress is present in the trabecular meshwork and posterior pole.

Conclusions:

  • Oxidative stress is implicated in the pathogenesis of glaucoma.
  • Therapeutic approaches for glaucoma should consider targeting oxidative stress.