The importance of Ca2+/Zn2+ signaling S100 proteins and RAGE in translational medicine

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Updated: Jun 1, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
11:10

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

Estelle Leclerc1, Claus W Heizmann

  • 1Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58108-6050, USA. Estelle.leclerc@ndsu.edu

Frontiers in Bioscience (Scholar Edition)
|May 31, 2011
PubMed

Insights

The Receptor for Advanced Glycation Endproducts (RAGE) binds S100 proteins, impacting numerous human disorders. This review explores RAGE and S100 protein roles in disease, highlighting their complex signaling pathways.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Biochemistry

Background:

  • The Receptor for Advanced Glycation Endproducts (RAGE) is a multiligand receptor implicated in various human diseases.
  • RAGE primarily binds Advanced Glycation Endproducts (AGEs) but also interacts with the S100 protein family.
  • The S100 protein family comprises over 20 small calcium-binding proteins with significant roles in cancer.

Purpose of the Study:

  • To review current knowledge on the involvement of S100 proteins and RAGE in human disorders.
  • To elucidate the interaction mechanisms and signaling pathways mediated by RAGE and S100 proteins.
  • To highlight the implications of these interactions in disease pathogenesis.

Main Methods:

  • Literature review of recent studies on RAGE and S100 proteins.
  • Analysis of signaling cascades triggered by S100-RAGE interactions.
  • Examination of the role of S100 proteins in cancer and other human disorders.

Main Results:

  • RAGE acts as a key receptor for numerous S100 proteins, including S100B and S100A12.
  • S100-RAGE interactions trigger cell-type and concentration-dependent signaling pathways.
  • Many S100 proteins are implicated in cancer development and progression.

Conclusions:

  • RAGE and S100 proteins are critical players in a wide range of human disorders.
  • Understanding their complex interactions is crucial for developing therapeutic strategies.
  • Further research into S100 protein functions and RAGE signaling is warranted.

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