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Related Concept Videos

Embryonic Connective Tissues01:20

Embryonic Connective Tissues

During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Uterine Tubes01:16

Uterine Tubes

The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jun 1, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Uterine mesenchymal tumors.

Nikhil A Sangle1, Subodh M Lele

  • 1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

Indian Journal of Pathology & Microbiology
|May 31, 2011
PubMed
Summary

Diagnosing uterine mesenchymal tumors is challenging. This review highlights key morphologic features for distinguishing benign from malignant types, crucial for patient outcomes.

Area of Science:

  • Gynecologic Pathology
  • Surgical Pathology
  • Oncology

Background:

  • Uterine mesenchymal tumors represent a diverse and diagnostically complex group of neoplasms.
  • Accurate differentiation between benign and malignant subtypes is critical for determining patient prognosis and guiding treatment strategies.
  • Surgical pathologists play a pivotal role in the accurate classification of these challenging tumors.

Purpose of the Study:

  • To emphasize the essential morphologic features for diagnosing uterine mesenchymal tumors.
  • To provide guidance on differentiating these neoplasms from their mimics.
  • To briefly describe relevant immunohistochemical features supporting the morphologic assessment.

Main Methods:

  • Review of key morphologic characteristics of uterine mesenchymal tumors.

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09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

  • Comparative analysis of benign and malignant mesenchymal tumor features.
  • Discussion of relevant immunohistochemical markers.

    • Main Results:

    • Morphologic features are paramount in the diagnosis and classification of uterine mesenchymal tumors.
    • Specific histological patterns are critical for distinguishing benign from malignant entities.
    • Immunohistochemistry serves as a supportive tool, but diagnostic accuracy relies primarily on morphology.

    Conclusions:

    • Accurate diagnosis of uterine mesenchymal tumors relies heavily on meticulous evaluation of morphologic features.
    • Understanding key histological distinctions is essential for surgical pathologists.
    • This review provides a framework for improved diagnostic accuracy in challenging cases.