Related Experiment Video
Updated: Jun 1, 2026

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
Published on: June 24, 2025
Do catheters harm the patient?
1Vivantes Klinikum im Friedrichshain, Berlin, Germany.
Insights
Central venous catheters (CVCs) are increasingly used for hemodialysis (HD) but pose significant infection risks, especially early in treatment. Peritoneal dialysis (PD) should be prioritized over CVCs for end-stage renal disease patients.
Area of Science:
- Nephrology
- Vascular Access
- Infectious Disease
Background:
- Central venous catheters (CVCs) are frequently the initial vascular access for incident hemodialysis (HD) patients.
- CVC use is linked to procedural and long-term complications, including bacteremia and sepsis.
- Infection mortality risk is highest in the first six months of HD initiation.
Purpose of the Study:
- To evaluate the risks associated with CVC use in incident hemodialysis patients.
- To compare infection risks between CVCs and peritoneal dialysis (PD).
- To advocate for alternative vascular access strategies.
Main Methods:
- Review of complications associated with CVC insertion, dwell time, and removal.
- Comparative analysis of infection rates between hemodialysis and peritoneal dialysis vascular access.
- Assessment of mortality risks linked to CVC-related infections.
Main Results:
- CVCs present short-term insertion risks and long-term intravascular complications.
- Bacteremia and sepsis are the most critical CVC-associated risks.
- The infection risk with CVCs in HD patients now surpasses that in PD patients.
Conclusions:
- Central venous catheters should be the last resort for vascular access in hemodialysis.
- Peritoneal dialysis should be considered before CVCs for permanent vascular access in end-stage renal disease.
- Minimizing CVC use is crucial for reducing infection-related mortality in incident HD patients.
Abstract:
There is an increasing use of central venous catheters (CVCs) as a first-line vascular access in incident hemodialysis (HD) patients. CVCs are associated with short-term complications related to the catheter insertion procedure and with long-term complications as a consequence of the intravascular interaction of catheter material with the venous endothelium. Removal of CVCs is also associated with specific risks, such as pulmonary or air embolism. Bacteremia and sepsis, however, are the most important risks associated with CVCs. In incident HD patients, the mortality risk from infection is highest during the first 6 months after dialysis initiation, and has steadily increased over the last decade. The relative risk for infection from CVCs in HD patients now clearly exceeds the risk for catheter-related infections in peritoneal dialysis (PD) patients. CVCs should therefore always be the last preference for vascular access in HD. The option for PD should always be evaluated before using CVCs as a permanent vascular access in end-stage renal disease patients.
More Related Videos
Related Concept Videos
Cardiac Catheterization IV: Nursing Management
Cardiac Catheterization I: Pre-Procedure Overview
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Cardiac Catheterization II: Right Heart Catheterization
Cardiac Catheterization III: Left Heart Catheterization
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

