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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...

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Related Experiment Video

Updated: Jun 1, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Recent trials on hemodiafiltration.

Francesco Locatelli, Celestina Manzoni, Lucia Del Vecchio

    Contributions to Nephrology
    |June 1, 2011
    PubMed
    Summary
    This summary is machine-generated.

    High-flux hemodialysis (HD) offers theoretical benefits for chronic kidney disease (CKD) patients. While studies show mixed results, high-flux HD may improve survival in specific high-risk or diabetic CKD patients.

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
    07:11

    Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

    Published on: July 19, 2018

    Area of Science:

    • Nephrology
    • Renal Replacement Therapy

    Background:

    • High-flux hemodialysis (HD) theoretically enhances toxin removal and biocompatibility for chronic kidney disease (CKD) patients.
    • Observational studies suggest positive effects of high-flux HD on uremic patient survival and morbidity compared to low-flux HD.

    Purpose of the Study:

    • To evaluate the effectiveness of high-flux hemodialysis (HD) and on-line hemodiafiltration (HDF) in treating patients with chronic kidney disease (CKD).
    • To assess the impact of different dialysis modalities on patient survival and morbidity.

    Main Methods:

    • Review of observational studies and prospective randomized trials, including the HEMO and MPO studies.
    • Comparison of high-flux HD, low-flux HD, and on-line hemodiafiltration (HDF) based on solute clearance and patient outcomes.

    Main Results:

    • The HEMO study's primary analysis showed a nonsignificant mortality reduction with high-flux HD versus low-flux HD.
    • The MPO study indicated improved survival with high-flux HD in high-risk patients (serum albumin ≤4 g/dl) and diabetic patients.
    • On-line HDF demonstrates higher clearance of small and middle molecules compared to high-flux HD.

    Conclusions:

    • High-flux HD shows potential survival benefits in specific CKD patient subgroups.
    • Further large randomized controlled trials are needed to confirm the survival and morbidity advantages of on-line HDF over high-flux HD.