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Acyclic identification of aptamers for human alpha-thrombin using over-represented libraries and deep sequencing

Gillian V Kupakuwana1, James E Crill, Mark P McPike

  • 1Graduate Program in Structural Biology, Biochemistry and Biophysics, Syracuse University, Syracuse, New York, United States of America.

Plos One
|June 1, 2011
PubMed
Summary

Aptamer discovery is accelerated by over-representing sequences and using deep sequencing, enabling acyclic identification of high-affinity aptamers for targets like human alpha-thrombin.

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