Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases.

Annals of clinical and translational neurology·2017
Same author

PREDICT-PD: An online approach to prospectively identify risk indicators of Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society·2017
Same author

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging.

Cell reports·2017
Same author

The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis".

The FEBS journal·2017
Same author

ATXN2 trinucleotide repeat length correlates with risk of ALS.

Neurobiology of aging·2016
Same author

Weighted Protein Interaction Network Analysis of Frontotemporal Dementia.

Journal of proteome research·2016
Same journal

Gene Therapy for Amino Acid Decarboxylase Deficiency: Clinical and Imaging Outcomes in a French Cohort.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Alzheimer's Disease Cerebrospinal Fluid Biomarkers Predict Survival in Progressive Supranuclear Palsy.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Longitudinal Dynamics of Polyglutamine-Expanded ATXN3 in Biofluids of Spinocerebellar Ataxia Type 3.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Putamen Structural-Functional Decoupling as an Early-Stage Candidate Imaging Marker for Motor Severity in Spinocerebellar Ataxia Type 3.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Melanopsin-Mediated Post-Illumination Pupillary Response in Idiopathic Rapid Eye Movement (REM) Sleep Behavior Disorder and Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2026

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons
09:21

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Milestones in PD genetics.

Thomas Gasser1, John Hardy, Yoshikuni Mizuno

  • 1Hertie-Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, and German Center for Neurodegenerative Diseases, Tübingen, Germany. Thomas.Gasser@uni-tuebingen.de

Movement Disorders : Official Journal of the Movement Disorder Society
|June 1, 2011
PubMed
Summary
This summary is machine-generated.

Genetic discoveries over 25 years reveal Parkinson's disease (PD) causes. Both rare mutations and common variants in multiple genes contribute to PD risk and progression, offering new treatment targets.

More Related Videos

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
08:55

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

Related Experiment Videos

Last Updated: Jun 1, 2026

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons
09:21

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
08:55

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

Area of Science:

  • Neurogenetics
  • Molecular Biology

Background:

  • Genetic research has significantly advanced understanding of Parkinson's disease (PD) etiology over the past 25 years.
  • Linkage studies and positional cloning identified numerous genes responsible for rare monogenic forms of PD (autosomal-dominant and autosomal-recessive).

Observation:

  • Whole-genome association studies demonstrate that low-penetrance variants in these and other genes contribute to the common sporadic form of PD.
  • Rare variants, such as those in glucocerebrosidase A linked to Gaucher's disease, are identified as significant risk factors for PD.

Findings:

  • An intricate genetic network influencing PD risk and progression is emerging.
  • Next-generation sequencing is anticipated to uncover additional genetic variants contributing to PD.

Implications:

  • Identified genetic factors provide crucial entry points for developing targeted, disease-modifying therapies for Parkinson's disease.
  • Understanding the genetic architecture of PD is essential for designing rational therapeutic strategies.