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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Biomedical applications of tetrazine cycloadditions

Neal K Devaraj1, Ralph Weissleder

  • 1Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA. ndevaraj@ucsd.edu

Accounts of Chemical Research
|June 2, 2011
PubMed
Summary

Researchers developed extremely rapid bioorthogonal coupling reactions using tetrazines and strained alkenes for precise molecular labeling in cells and in vivo. This advance enables real-time imaging, diagnostics, and targeted cancer therapy with improved signal amplification.

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