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Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst

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Published on: April 22, 2016

Functional virus-based polymer-protein nanoparticles by atom transfer radical polymerization.

Jonathan K Pokorski¹, Kurt Breitenkamp, Lars O Liepold

¹Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Journal of the American Chemical Society

|June 2, 2011

Summary

Virus-like particles (VLPs) serve as versatile platforms for creating novel protein-polymer conjugates. This study demonstrates their use in atom transfer radical polymerization for advanced biomedical applications.

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Area of Science:

Biotechnology
Polymer Chemistry
Nanotechnology

Background:

Viruses and virus-like particles (VLPs) possess unique structural properties beneficial for biomedical research.
VLPs offer a scaffold for engineered interactions across large molecular surface areas.

Purpose of the Study:

To utilize VLPs as multivalent macroinitiators for atom transfer radical polymerization (ATRP).
To develop a robust platform for post-synthetic modification of protein-polymer conjugates.

Main Methods:

Employing VLPs as macroinitiators in atom transfer radical polymerization.
Incorporating chemically reactive monomers during polymerization.
Utilizing copper-catalyzed azide-alkyne cycloaddition for post-synthetic modification.

Main Results:

Demonstrated successful polymerization initiated by VLPs.
Achieved post-synthetic modification of the resulting protein-polymer conjugates.
Established a versatile method for creating complex nanostructures.

Conclusions:

VLPs are effective macroinitiators for ATRP, enabling the synthesis of protein-polymer conjugates.
The developed platform facilitates the construction of nanoparticle delivery vehicles and imaging agents.
This approach provides a foundation for advanced biomaterials and nanomedicine.