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Malakoplakia. Two unusual cases which presented diagnostic problems.

T V Colby

    The American Journal of Surgical Pathology
    |December 1, 1978
    PubMed
    Summary
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    Two rare malakoplakia cases occurred outside the urinary tract, presenting diagnostic challenges. Limited Michaelis-Guttman bodies in these unusual sites mimicked other serious conditions.

    Area of Science:

    • Pathology
    • Oncology
    • Urology

    Background:

    • Malakoplakia is a rare inflammatory condition typically affecting the urinary tract.
    • Diagnosis often relies on identifying Michaelis-Guttman bodies, which are pathognomonic calcified inclusions.

    Observation:

    • This report details two atypical malakoplakia cases presenting outside the urinary tract: one in the retroperitoneum and another in the perianal region.
    • Both cases posed diagnostic difficulties due to the scarcity or absence of typical Michaelis-Guttman bodies.

    Findings:

    • The retroperitoneal case was initially misdiagnosed as a malignant fibrous histiocytoma.
    • The perianal case resembled a common perianal abscess, highlighting the varied clinical presentations.

    Implications:

    Related Experiment Videos

    • These cases underscore the importance of considering malakoplakia in the differential diagnosis of masses in unusual locations, even with limited pathognomonic signs.
    • Awareness of these atypical presentations can improve diagnostic accuracy and patient management for rare inflammatory conditions.