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Related Concept Videos

Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...

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Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

Aphasic status epilepticus: electroclinical correlation.

Eric J Ericson1, Elizabeth E Gerard, Michael P Macken

  • 1Department of Neurology, Northwestern University, Chicago, Illinois 60611, USA. e-ericson@md.northwestern.edu

Epilepsia
|June 2, 2011
PubMed
Summary
This summary is machine-generated.

Aphasic status epilepticus (ASE) is rare. Continuous EEG is crucial for diagnosis and treatment, as standard EEG and clinical symptoms alone are insufficient for managing this condition.

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Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
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Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Area of Science:

  • Neurology
  • Epileptology
  • Neurophysiology

Background:

  • Aphasic status epilepticus (ASE) is an uncommon condition characterized by epileptic seizures presenting with aphasia in awake patients.
  • This study investigates clinical, electrophysiologic, and imaging findings in a series of nine consecutive ASE patients.

Observation:

  • Nine right-handed patients with ASE were identified, all presenting with left hemispheric lesions on MRI.
  • Patients exhibited mixed aphasia, with speech deficits persisting in most cases.
  • Initial EEG recordings detected electrographic seizures in only 56% of patients, highlighting limitations of standard EEG.

Findings:

  • Continuous video-electroencephalography (EEG) monitoring confirmed electrographic seizure activity in all nine patients.
  • Left hemispheric periodic lateralized epileptiform discharges (PLEDS) and slowing were observed in some patients.
  • Clinical improvement was delayed, and aphasia persisted in some patients even after EEG seizure resolution.

Implications:

  • Standard EEG may not be sufficient for diagnosing ASE; continuous EEG monitoring is essential.
  • Clinical symptoms of aphasia do not reliably correlate with electrographic seizure activity, necessitating objective EEG data for treatment guidance.
  • Understanding these findings is critical for optimizing the diagnosis and management of aphasic status epilepticus.