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[Ankylosing spondylitis is associated with increased cardiovascular morbidity and mortality]

Ole Rintek Madsen1, Jesper Lindhardsen

  • 1Reumatologisk Funktion, Medicinsk Afdeling C, Gentofte Hospital, 2900 Hellerup, Denmark. rintek@dadlnet.dk

Ugeskrift for Laeger
|June 2, 2011
PubMed

Insights

Ankylosing spondylitis patients face higher cardiovascular risks due to inflammation and potential treatment side effects. Managing traditional risk factors is crucial for better heart health outcomes in these individuals.

Area of Science:

  • Rheumatology
  • Cardiology

Context:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease impacting the axial skeleton.
  • AS is linked to elevated cardiovascular morbidity and mortality.
  • Inflammation-driven cardiac structural changes and atherosclerosis are potential concerns.

Purpose:

  • To explore the cardiovascular risk profile in patients with ankylosing spondylitis.
  • To investigate the influence of traditional cardiovascular risk factors and anti-inflammatory therapies on cardiovascular outcomes in AS.
  • To assess the impact of tumor necrosis factor inhibitors on lipid profiles.

Summary:

  • Ankylosing spondylitis patients exhibit increased cardiovascular risk.
  • The precise roles of conventional risk factors and anti-inflammatory treatments require further elucidation.
  • Tumor necrosis factor inhibitors may elevate cholesterol levels, necessitating careful monitoring.

Impact:

  • Highlights the need for comprehensive cardiovascular risk assessment in AS patients.
  • Emphasizes the importance of managing cardiovascular risk factors according to established guidelines.
  • Suggests a potential link between specific AS treatments and adverse lipid changes.

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