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[Ankylosing spondylitis is associated with increased cardiovascular morbidity and mortality]
Ole Rintek Madsen1, Jesper Lindhardsen
1Reumatologisk Funktion, Medicinsk Afdeling C, Gentofte Hospital, 2900 Hellerup, Denmark. rintek@dadlnet.dk
Abstract:
Ankylosing spondylitis is an inflammatory disorder primarily affecting the axial skeleton. The disease is associated with increased cardiovascular morbidity and mortality. Structural changes in the heart, and arteriosclerosis secondary to inflammation may be of importance. The role of traditional cardiovascular risk factors and of anti-inflammatory treatment is unclear. Tumor necrosis factor inhibitors seem to increase cholesterol levels. Evaluation of the cardiovascular risk in these patients should be considered. Cardiovascular risk factors should be managed according to ordinary guidelines.
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