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Updated: Jun 1, 2026
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Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
Published on: August 19, 2025
Treatment for breast sarcoma: a large, single-centre series.
T Pencavel1, C P Allan, J M Thomas
1Sarcoma/Melanoma Unit, Department of Academic Surgery, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom. tim.pencavel@icr.ac.uk
Summary
Outcomes for breast sarcoma patients treated at a specialist center show improved disease-free survival. Early surgery at high-volume units reduces involved margins and local recurrence, especially for radiation-induced sarcomas.
Area of Science:
- Oncology
- Surgical Oncology
- Radiotherapy
Background:
- Breast sarcoma is a rare malignancy.
- Outcomes can be influenced by treatment setting and prior radiotherapy.
Purpose of the Study:
- To evaluate treatment outcomes for breast sarcoma patients.
- To compare outcomes based on surgical management and referral patterns.
Main Methods:
- Retrospective analysis of 63 histologically-proven breast sarcoma patients (1996-2006).
- Kaplan-Meier survival analysis and Log-Rank/Wilcoxon tests.
- Comparison of outcomes between primary surgery at a specialist unit versus referring institutions.
Main Results:
- Patients treated at a high-volume sarcoma unit had better 2-year (84% vs. 75%) and 5-year (58% vs. 37%) disease-free survival.
- Involved margins were significantly lower (10% vs. 61%) when primary surgery was performed at the specialist institution.
- Radiation-induced breast sarcomas had worse local recurrence rates and a higher proportion required mastectomy.
Conclusions:
- Specialist management of breast sarcoma is associated with improved outcomes.
- Minimizing involved margins through expert surgical care is crucial for better disease-free survival.
- Radiation-induced breast sarcomas present unique challenges with higher recurrence rates.
