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Updated: Jun 1, 2026
10:25
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
Published on: September 20, 2019
[Cutaneous lymphoma and chemokine]
1Department of Dermatology, Faculty of Medicine, University of Tokyo.
Summary
Chemokines and their receptors are key to understanding skin-specific cancers like cutaneous lymphoma. Targeting these molecules shows promise for new treatments for this T cell lymphoma.
Area of Science:
- Immunology
- Dermatology
- Oncology
Background:
- Chemokines and chemokine receptors exhibit organ-specific expression patterns.
- Cutaneous lymphoma, a skin-specific cancer, involves lymphocyte proliferation without systemic involvement.
- Mycosis fungoides and Sezary syndrome are common types of cutaneous T cell lymphoma.
Purpose of the Study:
- To investigate the role of specific chemokines and receptors in cutaneous lymphoma pathogenesis.
- To explore the potential of chemokine-targeting biologics as therapeutic strategies.
Main Methods:
- Analysis of chemokine and chemokine receptor expression in lesional skin and serum.
- Evaluation of the in vitro and ex vivo effects of anti-CCR4 monoclonal antibody on lymphoma cells.
Main Results:
- CCL17, CCL27, CCL11, and CCL26 are elevated in cutaneous lymphoma and correlate with disease progression.
- CXCL9, CXCL10, CCL21, and CXCL12 are implicated in tumor cell behavior and invasion.
- Expression of CXCL13 and CCR3 is relevant in specific cutaneous lymphoma contexts.
- Anti-CCR4 antibody demonstrated significant antitumor activity against CCR4+ lymphoma cells.
Conclusions:
- Chemokines and chemokine receptors play crucial roles in cutaneous lymphoma development and progression.
- Targeting chemokines and their receptors, such as with anti-CCR4 therapy, offers a promising therapeutic avenue.
- Further research can lead to novel classifications, better understanding of pathogenesis, and advanced treatments for cutaneous lymphoma.
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