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Factors associated with blood pressure control in diabetic patients treated in nephrology units. PRESDIAB Study
N Serra1, A Oliveras, S Bergoñon
1Nephrology Department, Clínic Hospital, Barcelona, Spain.
Insights
Tight blood pressure control is achieved by less than 20% of type 2 diabetes patients in nephrology units. High LDL cholesterol levels are significantly associated with uncontrolled hypertension in this population.
Area of Science:
- Nephrology
- Cardiology
- Endocrinology
Background:
- Hypertension management in diabetic patients remains a significant clinical challenge.
- Type 2 diabetes (DM2) patients often exhibit suboptimal blood pressure (BP) control.
- Nephrology units manage a high-risk population with co-existing DM2 and arterial hypertension (AHT).
Purpose of the Study:
- To determine the prevalence of tight BP control (<130/80mm Hg) in DM2 patients treated in nephrology units.
- To identify factors associated with achieving or failing to achieve target BP in this cohort.
- To inform clinical strategies for improving BP management in diabetic hypertensive patients.
Main Methods:
- An observational, cross-sectional study design was employed.
- 526 patients with DM2 and AHT were included in the analysis.
- Data collected included demographics, clinical characteristics, BP, kidney function, glycemic control, lipid profile, and medications.
Main Results:
- Only 17.5% of patients achieved tight BP control (<130/80mm Hg).
- Elevated LDL cholesterol levels were significantly associated with uncontrolled BP (OR 0.55; 95% CI:0.41-0.75).
- A majority of patients (71%) were on two or more antihypertensive medications.
Conclusions:
- Less than 20% of DM2 patients in nephrology units achieve target BP control.
- Elevated cholesterol levels are a key factor linked to poor BP control in this population.
- Improved management of dyslipidemia may be crucial for optimizing BP control in diabetic hypertensive patients.
Background And Objective:
Most hypertensive patients do not reach target blood pressure (BP), especially if they are diabetic. The objective of the study is to assess the percentage of tight BP control, defined as BP<130/80mm Hg and identify factors associated with it in diabetic type 2 (DM2) patients treated in nephrology units.
Patients And Methods:
Observational and cross-sectional study; we included 526 patients with DM2 and arterial hypertension (AHT). We collected data on: demographics, anthropometrics, harmful habits, history of cardiovascular disease (CVD), blood pressure, kidney function, glycaemic control, lipid profile, and drug treatment, among others.
Results:
The mean age (SD) was 66 (10.6) years, 61% were male, 12.8% were smokers, 39.4% had a history of CVD, 72% had hypercholesterolemia, and 44% were obese. Seventeen point five percent of patients had tight BP control (<130/80mm Hg) (95% confidence interval [CI]:14.3-21.0), while 36.9% had BP below 140/85mm Hg. Seventy-one percent of patients were prescribed two or more anti-hypertensive treatments. Several factors are associated with tight BP control not being achieved, and the logistic regression analysis revealed that LDL cholesterol levels were significantly associated (odds ratio [OR] 0.55; 95% CI:0.41-0.75 for one standard deviation increase).
Conclusions:
Of the DM2 patients that attended the nephrology units, less than 20% achieved a tight BP control. Cholesterol levels seem to be the main factor associated with unsatisfactory BP control within our study population.
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