Related Experiment Video
Updated: Jun 1, 2026
08:39
Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
Published on: January 3, 2015
[Stem cell--is there any role in tumorigenic activity]
1Department of Oral and Maxillofacial Pathology, Government Dental College, Raipur, India. sonal_ankur@rediffmail.com
Turk Patoloji Dergisi
|June 2, 2011
Summary
Stem cells are crucial for tissue repair but can also drive cancer. The cancer stem cell hypothesis posits that cancer originates from these malignant stem cells, which self-renew and differentiate.
Area of Science:
- * Stem cell biology
- * Oncology
- * Molecular biology
Context:
- * Stem cells maintain tissue homeostasis and are explored for regenerative medicine.
- * Traditionally, cancer is viewed as a disease of accumulated mutations affecting cell proliferation.
- * Emerging evidence implicates stem cells in disease pathogenesis, particularly cancer.
Purpose:
- * To explore the dual role of stem cells in homeostasis and disease.
- * To present the cancer stem cell hypothesis as a new model for carcinogenesis.
- * To highlight the self-renewal and differentiation capabilities of cancer stem cells.
Summary:
- * Stem cells, vital for tissue repair, are increasingly recognized for their role in disease.
- * The cancer stem cell hypothesis (2006) proposes cancer is a stem cell disorder.
- * Cancer stem cells drive tumorigenesis through uncontrolled self-renewal and differentiation.
Impact:
- * Shifts the paradigm of cancer research towards stem cell-centric models.
- * Offers new therapeutic targets by focusing on cancer stem cell vulnerabilities.
- * Provides a framework for understanding cancer initiation and progression.
More Related Videos
Related Concept Videos
02:40Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
02:40Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
01:26Stem Cell Niche
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
01:19Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...