Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Constraints on the Epoch of Reionization Using the Non-Gaussianity of the Kinematic Sunyaev-Zel'dovich Effect from the South Pole Telescope and Herschel-SPIRE Observations.

Physical review letters·2024
Same author

Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

Physical review letters·2022
Same author

Important factors regarding the analysis of extracorporeal blood flow in extracorporeal cardiopulmonary resuscitation.

Resuscitation·2022
Same author

[CARL-Controlled reperfusion of the whole body].

Zeitschrift fur Herz-, Thorax- und Gefasschirurgie·2022
Same author

Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

Physical review letters·2021
Same author

Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

Living reviews in relativity·2020

Related Experiment Video

Updated: Jun 1, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Closed circuit MR compatible pulsatile pump system using a ventricular assist device and pressure control unit.

R Lorenz1, C Benk, J Bock

  • 1Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany. ramona.lorenz@uniklinik-freiburg.de

Magnetic Resonance in Medicine
|June 2, 2011
PubMed
Summary

This study validated a novel MR-compatible pump system for 3D flow simulations. The system demonstrated reliable performance in replicating pulsatile flow and accurately simulating aortic coarctation in vitro.

More Related Videos

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

Related Experiment Videos

Last Updated: Jun 1, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Flow Dynamics
  • Medical Imaging

Background:

  • Accurate in vitro simulation of cardiovascular flow is crucial for understanding hemodynamics and device performance.
  • Magnetic Resonance (MR) compatibility is essential for integrated imaging and flow studies.
  • Pulsatile flow simulation requires reliable pump systems capable of mimicking cardiac output.

Purpose of the Study:

  • To evaluate the performance and test-retest reliability of a closed-circuit, MR-compatible, pneumatically driven pump system.
  • To assess the system's ability to perform in vitro 3D flow simulations using a ventricular assist device as a pulsatile flow pump.
  • To validate the system by comparing in vitro flow characteristics with in vivo data in a thoracic aorta model with simulated aortic coarctation.

Main Methods:

  • A closed-circuit system was developed using an MR-compatible pneumatically driven pump and a ventricular assist device for pulsatile flow.
  • A stenosis phantom (60% lumen narrowing) was used to evaluate pump system performance and test-retest reliability via Bland-Altman analysis.
  • A rapid prototyping in vitro model of a normal thoracic aorta, including a flexible stenosis for aortic coarctation simulation, was integrated.
  • In vitro flow measurements were compared with in vivo data from the same subject.

Main Results:

  • The pump system demonstrated good test-retest reliability for in vitro flow measurements (mean difference = -0.016 m/s, limits of agreement = ±0.047 m/s).
  • Significant correlations (r = 0.9, P = 0.002) were found between in vivo and in vitro mean velocities.
  • Simulating increasing grades of aortic coarctation resulted in expected flow pattern changes, including post-stenotic jet flow and increased velocities.

Conclusions:

  • The evaluated MR-compatible pneumatically driven pump system is reliable for in vitro pulsatile flow simulation.
  • The system accurately replicates cardiovascular flow dynamics, including those associated with aortic coarctation.
  • This technology offers a valuable tool for in vitro cardiovascular research and device testing under MR guidance.