Related Experiment Video
Updated: Oct 2, 2025
Author Spotlight: Advancing Spectral Characterization of Physiological and Malperfused Tissues
Published on: July 5, 2024
[CARL-Controlled reperfusion of the whole body]
C Benk1, G Trummer1, J-S Pooth1
1Klinik für Herz- und Gefäßchirurgie, Universitätsklinikum Freiburg, Hugstetter Str. 55, 79106 Freiburg, Deutschland.
Background:
The incidence and mortality of acute cardiovascular arrest have been consistently high for decades.
Objective:
How to improve the currently unsatisfactory outcome after resuscitation regarding survival and neurological, especially cerebral, sequelae?
Material And Methods:
Development of a therapeutic approach to curtail ischemia/reperfusion injury in an animal model. Development of a device system optimized for resuscitation that can be used to implement controlled reperfusion of the whole body outside the hospital.
Results:
Establishment of CARL treatment in the clinic and in the treatment of OHCA patients. Transfer of the CARL treatment and system in a clinical observational study. First case reports in which patients survived OHCA without brain damage even after ischemia times up to 2 h.
Conclusion:
CARL treatment is potentially suitable to treat patients suffering from cardiovascular arrest refractory to treatment even for prolonged periods.
