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Related Experiment Videos

[Plexus neuropathy: tumor infiltration or radiation damage].

I Ebner1, H Anderl, G Mikuz

  • 1Universitätsklinik für Strahlentherapie, Innsbruck.

Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|June 1, 1990
PubMed
Summary

Breast cancer patients may develop plexus neuropathies due to tumor infiltration, not just radiation fibrosis. Surgical findings reveal this surprising cause, crucial for accurate diagnosis and treatment.

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[Not Available].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016

Area of Science:

  • Oncology
  • Neurology
  • Pathology

Background:

  • Plexus neuropathies are common in breast cancer patients post-surgery and radiotherapy.
  • Symptoms like pain and reflex loss mimic radiation fibrosis, complicating diagnosis.
  • Accurate diagnosis is vital for appropriate patient management.

Purpose of the Study:

  • To investigate the causes of plexus neuropathies in breast cancer patients.
  • To compare operative findings with post-mortem data.
  • To identify reliable diagnostic markers for distinguishing tumor infiltration from radiation fibrosis.

Main Methods:

  • Surgical exploration of plexus lesions in affected breast cancer patients.
  • Histopathological examination of excised tissue.

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  • Comparison of findings with a cohort of deceased breast cancer patients.

    • Main Results:

    • A high percentage of patients exhibited extensive tumor infiltration of the plexus.
    • Tumor infiltration was identified as a significant cause of neuropathy.
    • Distinct morphological and histopathological patterns were observed for tumor infiltration versus radiation fibrosis.

    Conclusions:

    • Tumor infiltration is a more frequent cause of plexus neuropathy in breast cancer patients than previously assumed.
    • Understanding lesion patterns can aid in clinical diagnosis.
    • Distinguishing between tumor infiltration and radiation fibrosis is critical for treatment decisions.