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Published on: March 3, 2021
Therapeutic hypothermia in acute ischemic stroke
Leonid I Groysman1, Benjamin A Emanuel, May A Kim-Tenser
1Department of Neurology, Division of Neurocritical Care/Stroke, University of Southern California, Los Angeles, California, USA.
Neurosurgical Focus
|June 3, 2011
Summary
Therapeutic hypothermia shows promise for acute stroke neuroprotection. Further research is needed to optimize temperature, timing, and patient selection for this stroke treatment.
Area of Science:
- Neurology
- Cardiovascular Research
- Emergency Medicine
Background:
- Induced hypothermia is established for neuroprotection in cardiac and neurovascular procedures.
- Experimental and translational studies support its use in ischemic cerebrovascular disease.
Purpose of the Study:
- To review mechanisms, techniques, and clinical trials of therapeutic hypothermia for acute stroke.
- To outline side effects and complications associated with this stroke intervention.
Main Methods:
- Review of experimental, translational, and clinical studies on therapeutic hypothermia in acute stroke.
- Examination of various induction methods, time windows, indications, and adjuvant therapies.
Main Results:
- Therapeutic hypothermia has been applied clinically for acute stroke management over the past decade.
- Existing data suggests potential benefits, but optimal parameters remain undefined.
Conclusions:
- Additional clinical trials are necessary to determine the ideal time window, temperature, and indications for therapeutic hypothermia in acute stroke.
- Further research will refine the application of this neuroprotective strategy for stroke patients.
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