Related Experiment Video
Updated: Jun 1, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
Published on: May 9, 2025
Modern concepts on the role of inflammation in pulmonary fibrosis
Robert J Homer1, Jack A Elias, Chun Gun Lee
1Department of Pathology, Yale School of Medicine, New Haven, Connecticut 06520-8070, USA. Robert.homer@yale.edu
Context:
Idiopathic pulmonary fibrosis is a uniformly lethal disease with limited biomarkers and no proven therapeutic intervention short of lung transplantation. Pulmonary fibrosis at one time was thought to be a result of inflammation in the lung. Although some forms of pulmonary fibrosis may result from inflammation, idiopathic pulmonary fibrosis is currently thought to result from cell death primarily and inflammation secondarily.
Objective:
To determine the role of inflammation in pulmonary fibrosis in light of our laboratory's published and unpublished research and published literature.
Data Sources:
Review based on our laboratory's published and unpublished experimental data with relevant background and clinical context provided.
Conclusions:
Although cell death is central to pulmonary fibrosis, the proper cytokine environment leading to macrophage polarization is also critical. Evaluation of this environment is promising both for the development of disease biomarkers and for targets for therapeutic intervention.
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06:29Adoptive Transfer of IL-33-Stimulated Macrophages into Bleomycin-Induced Mouse Models to Study Their Effect on Idiopathic Pulmonary Fibrosis In Vivo
Published on: May 5, 2023
03:38Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
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