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Updated: Jun 1, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
The importance of senescence in ionizing radiation-induced tumour suppression
1Department of Radiobiology, University of Defence in Brno, Hradec Králové, Czech Republic. vavrova@pmfhk.cz
Abstract:
Cellular senescence is a condition of longlasting proliferation arrest, induced in cells in response to various stressors. These stressors include telomere shortening and/or dysfunction, DNA damage, and oncogene signalling. Epithelial and mesenchymal cells and also tumour cells derived from these tissues are more resistant to radiation-induced apoptosis and respond to irradiation mainly by senescence. Senescence-associated molecular mechanisms related to the activation of canonical DNA damage pathway ATM-p53 as well as mechanisms related to the extracellular signals, cytokine increase and upregulation of their receptors are discussed in this review.
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