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Related Experiment Videos

Beta-adrenergic blockade decreases norepinephrine release in humans.

S G Rosen1, M A Supiano, T J Perry

  • 1Department of Medicine, Cornell University Medical College, New York, New York 10021.

The American Journal of Physiology
|June 1, 1990
PubMed
Summary

Beta-adrenergic blockade with propranolol (PRP) decreases norepinephrine release into tissues. This suggests sympathetic nervous system (SNS) activity is suppressed, not reflexively increased, by this treatment.

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Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Neuroendocrinology

Background:

  • Beta-adrenergic blockade is known to increase plasma norepinephrine (NE) levels.
  • This increase is often interpreted as a compensatory reflex increase in sympathetic nervous system (SNS) activity.
  • Plasma NE levels, however, are an indirect measure of SNS activity.

Purpose of the Study:

  • To investigate whether beta-adrenergic blockade alters extravascular NE release, a more direct measure of systemic SNS activity.
  • To determine the effect of propranolol on NE kinetics and release in healthy subjects.

Main Methods:

  • Development of a two-compartment model of NE kinetics to estimate extravascular NE release.
  • Sequential infusion of saline and propranolol (PRP) in nine healthy subjects.

Related Experiment Videos

  • Measurement of plasma NE levels and calculation of NE release and clearance rates.

    • Main Results:

    • Propranolol infusion increased plasma NE levels (P=0.05).
    • Extravascular NE release rate significantly decreased during PRP infusion (P=0.0002).
    • Plasma NE clearance declined (P=0.0001), while NE spillover into plasma remained unchanged (P=0.89).

    Conclusions:

    • Beta-adrenergic blockade with propranolol decreases extravascular NE release in humans.
    • Suppression of SNS activity may be an additional mechanism of action for nonselective beta-adrenergic antagonists.
    • The increase in plasma NE during PRP is likely due to reduced clearance, not increased release.