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Published on: January 3, 2013
Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms
Joseph P Glass1, Gulshan Parasher, Hugo Arias-Pulido
1University of New Mexico, Albuquerque, NM, USA. joseph.glass2@va.gov
Introduction:
Our study attempts to characterize mesothelin and GPR30 / estrogen receptor (ER) staining in pancreatic pathology.
Materials And Methods:
Immunohistochemical staining for mesothelin, GPR30, and ER was performed on a variety of pancreatic lesions.
Results:
24 of 42 (57%) adenocarcinomas stained for mesothelin, while 0 of 16 non-carcinomas (0%) stained (p = 0.0000784). 35 of 39 (90%) adenocarcinomas stained for GPR30, while only 4 of 15 (27%) non-carcinomas stained (p = 0.0000036). Apart from stromal staining in one case of mucinous cystic neoplasm, no cases stained for ER. 27 of 37 (73%) adenocarcinoma fine needle aspirates were positive for mesothelin.
Discussion:
GPR30 is more sensitive, but less specific than mesothelin for pancreatic adenocarcinoma. Mesothelin is detected in most adenocarcinoma fine needle aspirates. ER is rarely detected in pancreatic lesions.
