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Tuberculosis-associated chronic kidney disease.

Jobson Lopes de Oliveira¹, Geraldo Bezerra da Silva Junior, Elizabeth De Francesco Daher

¹Division of Nephrology, Department of Internal Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. jobson.lopes@hotmail.com

The American Journal of Tropical Medicine and Hygiene

|June 3, 2011

Summary

This summary is machine-generated.

Extrapulmonary tuberculosis (TB) can affect the kidneys, leading to chronic kidney disease even in young, healthy individuals. This case highlights genitourinary TB as a cause of renal impairment requiring prompt diagnosis and treatment.

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Area of Science:

Nephrology
Infectious Diseases
Radiology

Background:

Extrapulmonary tuberculosis (TB) comprises 15-20% of all TB cases.
Genitourinary TB is the third most common extrapulmonary site.
Early diagnosis and treatment are crucial for managing TB complications.

Observation:

A 20-year-old male presented with fever, flank pain, and oliguria, progressing to renal failure.
Imaging revealed a non-functioning right kidney with significant pyelocaliceal and ureteral dilation.
Biopsies confirmed caseous granulomas, indicative of TB.

Findings:

The patient was treated with a standard four-drug anti-TB regimen.
He achieved a favorable outcome but developed non-dialytic chronic kidney disease.
Renal function loss was directly attributed to genitourinary tuberculosis.

Implications:

This case underscores the potential for genitourinary TB to cause irreversible kidney damage.
Highlights the importance of considering TB in young patients with unexplained renal failure.
Emphasizes the need for timely diagnosis and management of extrapulmonary TB to prevent long-term sequelae.