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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue shock.

Senaka Rajapakse1

  • 1Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka.

Journal of Emergencies, Trauma, and Shock
|June 3, 2011
PubMed
Summary
This summary is machine-generated.

Dengue shock syndrome, a severe dengue complication, leads to high mortality. Early clinical diagnosis and supportive care are crucial as no specific treatments improve survival.

Keywords:
DHFDSSDenguecorticosteroidsfluidsmyocarditisshock

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Dengue shock syndrome is a life-threatening complication of dengue virus infection, particularly following secondary serotype infections.
  • It is characterized by increased vascular permeability, myocardial dysfunction, and dehydration, leading to multiorgan failure and high mortality.
  • The pathogenesis involves complex mechanisms including cytokine-induced endothelial dysfunction.

Purpose of the Study:

  • To review the clinical presentation, pathophysiology, diagnosis, and management of dengue shock syndrome.
  • To highlight the challenges in predicting disease progression and the lack of specific effective therapies.

Main Methods:

  • This review synthesizes information from existing literature on dengue shock syndrome.
  • Diagnosis relies on clinical assessment, supported by serological tests and viral detection.

Main Results:

  • Dengue shock syndrome has a rapid and relentless progression.
  • Current management focuses on meticulous fluid resuscitation and supportive care.
  • Corticosteroids and intravenous immunoglobulins have not demonstrated proven benefits.

Conclusions:

  • Dengue shock syndrome requires prompt clinical recognition and intensive supportive management.
  • There is an unmet need for specific therapies to improve survival rates in severe dengue cases.
  • Further research is needed to identify predictors of outcome and develop targeted treatments.