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Extraction of [18F]fluoride from [18O]water by a fast fibrous anion exchange resin
D M Jewett1, S A Toorongian, M A Bachelor
1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|January 1, 1990
Abstract:
[18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K2CO3. Extraction into methanol facilitated rapid evaporation and resolubilization of the [18F]fluoride as an ion pair. The resin was first dried in situ and rehydrated with [18O]H2O to avoid isotopic dilution of the target water.