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Related Concept Videos

Introduction to Functional Groups02:08

Introduction to Functional Groups


Functional groups are group of atoms with specific chemical properties that occur within organic molecules and sometimes denoted as “R”. Functional groups are found along the carbon backbone of macromolecules can form chains or rings of carbon atoms. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of common functional groups
The table below summarizes some of the major functional groups in organic chemistry. (The...
Overview of Functional Groups01:19

Overview of Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, certain functional groups will make a molecule hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each functional group is a unique...
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Membrane Domains01:18

Membrane Domains

The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the anterior...
Functional Groups02:45

Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...

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Related Experiment Video

Updated: Jun 1, 2026

Functional Complementation Analysis (FCA): A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
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Functional Complementation Analysis (FCA): A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways

Published on: June 24, 2016

An introduction to recognizing functional domains.

Gary D Stormo1

  • 1Washington University School of Medicine, St. Louis, Missouri.

Current Protocols in Bioinformatics
|June 3, 2011
PubMed
Summary
This summary is machine-generated.

This unit explores protein and DNA domain recognition, detailing methods like consensus sequences and alignment matrices. It highlights resources for identifying functional domains in nucleotide and protein sequences, including databases like Pfam and InterPro.

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Identification of Functional Protein Regions Through Chimeric Protein Construction
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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

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Related Experiment Videos

Last Updated: Jun 1, 2026

Functional Complementation Analysis (FCA): A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
09:27

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Published on: June 24, 2016

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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
12:04

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

Published on: October 3, 2018

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Domain recognition is crucial for understanding protein and DNA sequence function.
  • Accurate identification of functional domains aids in biological research and drug discovery.

Purpose of the Study:

  • To provide an overview of domain recognition methodologies in biological sequences.
  • To discuss resources for identifying functional domains in nucleotide and protein sequences.

Main Methods:

  • Discusses consensus sequences and alignment matrices (e.g., log-odds matrices) for domain representation.
  • Reviews resources for identifying functional domains in nucleotide sequences, such as transcription factor binding sites.
  • Highlights databases like Pfam and InterPro for protein sequence analysis.

Main Results:

  • Outlines key methods for representing sequence domains.
  • Identifies available resources for domain analysis in both DNA and protein sequences.
  • Provides an overview of widely used bioinformatics databases for sequence analysis.

Conclusions:

  • Effective domain recognition relies on appropriate representation methods and robust databases.
  • The discussed resources facilitate the identification of functional elements in genomic and proteomic data.
  • Understanding domain recognition is fundamental for advancing biological sequence analysis.