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Updated: Jun 1, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Metallocorrole dendrimers: sensitive corrole-chromium(V)-nitride spin probes for studying the solution structure of
Michael Pittelkow1, Theis Brock-Nannestad, Jesper Bendix
1Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark.
Abstract:
The corrole-chromium(V)-nitrido moiety is introduced as a uniquely sensitive EPR spin probe. We describe a series of corrole-centered poly(amidoamine) (PAMAM) dendrimers and the selective incorporation of the chromium(V)-nitrido moiety. The chromium-corrole cores are reactive toward both neutral and charged reagents, and the accessibility of the dendrimer cores enables easy manipulation of the spin probe. The spin probe reveals a pronounced solvent dependence of the solution-phase structure of the dendrimers.
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