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Updated: Jun 1, 2026

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States
Published on: June 29, 2021
Nonlinear pressure dependence of the interaction potential of dense protein solutions
Martin A Schroer1, Jonas Markgraf, D C Florian Wieland
1Faculty of Physics/DELTA, TU Dortmund, Maria-Goeppert-Mayer-Str. 2, 44227 Dortmund, Germany.
Abstract:
The influence of pressure on the structure and protein-protein interaction potential of dense protein solutions was studied and analyzed using small-angle x-ray scattering in combination with a liquid state theoretical approach. The structural as well as the interaction parameters of dense lysozyme solutions are affected by pressure in a nonlinear way. The structural properties of water lead to a modification of the protein-protein interactions below 4 kbar, which might have significant consequences for the stability of proteins in extreme natural environments.
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