Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations

(S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives.

Organic letters·2001

D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.

Journal of medicinal chemistry·2001

Rational design of highly diastereoselective, organic base-catalyzed, room-temperature Michael addition reactions.

The Journal of organic chemistry·2000

Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.

Biophysical journal·2000

Improved bioavailability to the brain of glycosylated Met-enkephalin analogs.

Brain research·2000

Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.

Urology·2000

Design rules for bioorthogonal glycan-based tools.

The Biochemical journal·2026

α-Galactosyl residues on Trypanosoma cruzi trypomastigote glycoconjugates contribute to host-cell invasion via Galectin-3 and Annexin A2-S100A10 complex.

The Biochemical journal·2026

KDM2B controls HIF levels and activity through its JmjC and CxxC domains.

The Biochemical journal·2026

Graph-based representations in modern protein science.

The Biochemical journal·2026

Probing biomolecular condensates with a minimally perturbative experimental readout framework.

The Biochemical journal·2026

SF3B4 'reads' RNA that is methylated by METTL16.

The Biochemical journal·2026

Strategy for modular assembly of tetravalent, multispecific antibodies.

Protein science : a publication of the Protein Society·2026

Synthesis, Conformational Analysis, and Evaluation of 6R- and 6S‑Methylmannoimidazoles as Mannosidase Inhibitors.

ACS omega·2026

Correction to "Design, Synthesis, and Biological Evaluation of Novel Tetrandrine Derivatives Targeting AKT1 for Hepatocellular Carcinoma Therapy: Integration of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation".

ACS omega·2026

Synthesis and Fundamental Evaluation of [67Ga]Ga-NOTA‑D‑KV6 as a Potential Cationic Amphiphilic Peptide Probe for Tumor Imaging.

ACS omega·2026

Computational Design of RNA Aptamers Targeting Oncogenic miR-10b Using T‑SELEX and Molecular Dynamics-Based Stability Metrics.

ACS omega·2026

Structure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility.

Frontiers in chemistry·2026

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Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and

Related Concept Videos

(S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives.

D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.

Rational design of highly diastereoselective, organic base-catalyzed, room-temperature Michael addition reactions.

Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.

Improved bioavailability to the brain of glycosylated Met-enkephalin analogs.

Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.

Design rules for bioorthogonal glycan-based tools.

α-Galactosyl residues on Trypanosoma cruzi trypomastigote glycoconjugates contribute to host-cell invasion via Galectin-3 and Annexin A2-S100A10 complex.

KDM2B controls HIF levels and activity through its JmjC and CxxC domains.

Graph-based representations in modern protein science.

Probing biomolecular condensates with a minimally perturbative experimental readout framework.

SF3B4 'reads' RNA that is methylated by METTL16.

Strategy for modular assembly of tetravalent, multispecific antibodies.

Synthesis, Conformational Analysis, and Evaluation of 6R- and 6S‑Methylmannoimidazoles as Mannosidase Inhibitors.

Correction to "Design, Synthesis, and Biological Evaluation of Novel Tetrandrine Derivatives Targeting AKT1 for Hepatocellular Carcinoma Therapy: Integration of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation".

Synthesis and Fundamental Evaluation of [67Ga]Ga-NOTA‑D‑KV6 as a Potential Cationic Amphiphilic Peptide Probe for Tumor Imaging.

Computational Design of RNA Aptamers Targeting Oncogenic miR-10b Using T‑SELEX and Molecular Dynamics-Based Stability Metrics.

Structure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility.

Related Experiment Videos

Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and...

Related Concept Videos

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Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and