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Microbiological cure times in acanthamoeba keratitis
C E Oldenburg1, J D Keenan, V Cevallos
1Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA, USA.
Eye (London, England)
|June 4, 2011
Summary
Acanthamoeba keratitis treatment duration averaged 6 weeks, with significant predictors like initial visual acuity influencing clearance time. This study provides key insights into Acanthamoeba infection clearance.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Acanthamoeba keratitis is a serious eye infection.
- The duration of treatment and factors influencing clearance are not well understood.
Purpose of the Study:
- To estimate the treatment duration for Acanthamoeba keratitis to achieve negative laboratory test results.
- To identify predictors affecting the clearance time of Acanthamoeba infections.
Main Methods:
- Retrospective analysis of patients with laboratory-confirmed Acanthamoeba keratitis from 1996-2009.
- Parametric survival analysis and simulations were used to estimate clearance time and identify predictors.
- Imperfect sensitivity of diagnostic tests was considered in estimations.
Main Results:
- Median clearance time was 42.5 days (IQR 22.0-82.0 days) in patients with repeat cultures.
- Initial visual acuity was a significant predictor of clearance time (P<0.0001).
- Estimated median clearance time ranged from 38.7 to 44.1 days, considering predictors and test sensitivity.
Conclusions:
- The study estimates a median clearance time of approximately 6 weeks for Acanthamoeba keratitis.
- Initial visual acuity is a key factor influencing the duration of Acanthamoeba infection clearance.
- Further characterization of treatment duration is crucial for managing Acanthamoeba keratitis.
