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Related Concept Videos

The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The DNA Helix01:16

The DNA Helix

Overview
DNA Packaging00:58

DNA Packaging

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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Related Experiment Video

Updated: Jun 1, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Recent progress in DNA origami technology.

Masayuki Endo1, Hiroshi Sugiyama

  • 1Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan.

Current Protocols in Nucleic Acid Chemistry
|June 4, 2011
PubMed
Summary
This summary is machine-generated.

DNA origami enables precise 2D and 3D nanostructure design. This review covers programmed assembly, templated molecular assembly, functionalization, and nanomachines built using DNA origami technology.

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Designing a Bio-responsive Robot from DNA Origami

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Last Updated: Jun 1, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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Published on: September 27, 2019

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Area of Science:

  • Nanotechnology
  • Molecular Biology
  • Biochemistry

Background:

  • DNA origami is a rapidly advancing technology for creating nanoscale structures.
  • It allows for the precise arrangement of DNA strands into complex two-dimensional and three-dimensional shapes.

Purpose of the Study:

  • To review key advancements and applications in DNA origami research.
  • To highlight diverse studies including programmed assembly, molecular templating, and nanomachinery.

Main Methods:

  • Exploration of programmed DNA origami assembly techniques.
  • Investigation of DNA origami as a scaffold for molecular assembly.
  • Design and construction methodologies for 3D DNA origami structures.
  • Methods for functionalizing DNA origami and integrating with top-down nanotechnology.
  • Techniques for single-molecule observation of DNA origami.
  • Development of DNA nanomachines operating on DNA origami scaffolds.

Main Results:

  • Demonstration of programmed assembly for controlled nanostructure formation.
  • Successful templating of molecular components using DNA origami scaffolds.
  • Creation of intricate 3D DNA origami architectures.
  • Integration of functional elements and combination with conventional nanotechnology.
  • Advancements in visualizing and analyzing DNA origami at the single-molecule level.
  • Development of functional DNA nanomachines for specific tasks.

Conclusions:

  • DNA origami is a versatile platform with broad applications in nanotechnology and molecular assembly.
  • Ongoing research continues to expand the capabilities and complexity of DNA origami structures and devices.