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Related Concept Videos

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
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Thermosensitive and dissolution properties in nanocomposite polymer hydrogels.

Chia-Jung Wu1, Gudrun Schmidt

  • 1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.

Macromolecular Rapid Communications
|June 4, 2011
PubMed
Summary

This study developed thermo-sensitive nanocomposite hydrogels using Pluronic F127 and Laponite nanoparticles. Adding nanoparticles significantly improved dissolution resistance and slowed drug release, enhancing their potential for sustained drug delivery.

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Area of Science:

  • Materials Science
  • Polymer Science
  • Nanotechnology

Background:

  • Thermo-sensitive hydrogels like Pluronic F127 are promising for drug delivery but suffer from rapid dissolution.
  • The rapid dissolution limits their application as effective sustained release drug carriers.
  • Nanoparticle integration offers a potential strategy to enhance hydrogel stability and drug release profiles.

Purpose of the Study:

  • To investigate the phase transition and dissolution resistant properties of thermo-sensitive nanocomposite hydrogels.
  • To explore the synergistic effects of Pluronic F127 and Laponite nanoparticles on hydrogel behavior.
  • To demonstrate the potential of these nanocomposite hydrogels for sustained drug delivery applications.

Main Methods:

  • Fabrication of thermo-sensitive nanocomposite hydrogels using Pluronic F127 and Laponite silicate nanoparticles.
  • Characterization of phase transition temperatures as a function of hydrogel composition.
  • Evaluation of hydrogel dissolution rates and model drug (albumin) release kinetics.

Main Results:

  • The addition of Laponite nanoparticles significantly enhanced the dissolution resistance of Pluronic F127 hydrogels.
  • The temperature-dependent phase transitions of the hydrogels could be tuned by adjusting the nanoparticle content.
  • Nanoparticle incorporation effectively slowed down the release of albumin, indicating improved sustained release capabilities.

Conclusions:

  • Thermo-sensitive nanocomposite hydrogels combining Pluronic F127 and Laponite nanoparticles offer enhanced stability and controlled drug release.
  • The synergistic interaction between the polymer and nanoparticles overcomes the limitations of rapid dissolution in traditional hydrogels.
  • These developed hydrogels show significant promise for future applications in advanced drug delivery systems.