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Updated: Jun 1, 2026

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
Published on: July 27, 2022
[Expression of platelet-derived growth factor receptor α and its ligand PDGF- A in breast cancer]
De-shui Liu1, Xiao-jie Zhang, Gang Chen
1Qiqihar Medical College, Heilongjiang Province, Qiqihar 161006, China.
Aim:
To investigate the potential significance of platelet-derived growth factor receptor-α (PDGFR-α) and platelet-derived growth factor A (PDGF-A) expression in mammary carcinomas, and analyze its correlation with the lymph node metastasis and the expression of PDGF-A.
Methods:
Used immunohistochemistry to detect the protein expression of PDGFR-α and PDGF-A in paraffinembedded breast carcinomas.
Results:
The expression of PDGFR-α and PDGF-A were observed in 51.7% and 61.7% in the breast carcinomas, respectively and showed an association with lymph node metastasis (P < 0. 05). A correlation was also found with the expression of PDGFR-α and PDGF-A (P<0.05).
Conclusion:
PDGFR-α is expressed in invasive breast carcinomas and is associated with biological aggressiveness.
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