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Updated: Jun 1, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Benefits of cardiac resynchronization therapy in "very dilated cardiomyopathy"

Ana Lousinha1, Mário M Oliveira, Joana Feliciano

  • 1Serviço de Cardiologia, Hospital de Santa Marta, Lisboa, Portugal. lousinha@hotmail.com

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|June 7, 2011
PubMed

Insights

Patients with very dilated cardiomyopathy showed a higher clinical response rate to cardiac resynchronization therapy (CRT). However, reverse remodeling was similar across groups, indicating LVEDD may not solely predict CRT success.

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is used for advanced heart failure.
  • Left ventricular end-diastolic dimension (LVEDD) is a potential predictor of CRT response.

Purpose of the Study:

  • To investigate CRT response in patients with very dilated cardiomyopathy (LVEDD ≥ 45 mm/m²).
  • To compare responder rates and reverse remodeling between patients with very dilated cardiomyopathy and those with less dilated ventricles (37 mm/m² < LVEDD < 45 mm/m²).

Main Methods:

  • Retrospective analysis of 71 heart failure patients undergoing CRT.
  • Patients were divided into two groups based on LVEDD: Group A (very dilated) and Group B.
  • Echocardiography assessed NYHA class, LVEF, and LVEDD at baseline and 6 months post-CRT.

Main Results:

  • Overall, 79% of patients were clinical responders with improved LVEF and reduced LVEDD.
  • Very dilated cardiomyopathy patients (Group A) showed a significantly higher clinical responder rate (96% vs. 72%).
  • Reverse remodeling, LVEF improvement, and LVEDD reduction were similar between groups.

Conclusions:

  • A significant number of patients achieve reverse remodeling after CRT.
  • While very dilated cardiomyopathy patients exhibit better functional class improvement, the degree of reverse remodeling is comparable across LVEDD groups.
Abstract

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