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Hypocholesterolemic Effects of N-[(2-Hydroxy-3-N,N-Dimethylhexadecyl Ammonium)Propyl] Chitosan Chloride in
Xiaofei Liu1, Anrong Zeng, Tao Song
1a Department of Polymer Materials Science and Engineering, College of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China; Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, P. R. China. liuxf@tju.edu.cn.
Abstract:
In this paper, the potential hypocholesterolemic effect of N-[(2-hydroxy-3-N,N-dimethylhexadecyl ammonium)propyl] chitosan chloride (N-CQCs) was studied. In vivo hypocholesterolemic tests of N-CQCs were carried out to examine the effect on LDL, HDL, TC, leptin, FFA and SOD. The results showed that LDL, TC, leptin and FFA were decreased after supplementation with N-CQCs in the high-fat diet, preliminarily indicating that N-CQCs have a better hypocholesterolemic effect than chitosan. SOD was significantly elevated by N-CQCs compared with that of HF and HFC groups. N-CQCs increased antioxidant activity of SOD, indicating that N-CQCs regulated antioxidant enzyme activities and might reduced lipid peroxidation.
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