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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

MR diffusion imaging in ischemic stroke

Steve H Fung1, Luca Roccatagliata, R Gilberto Gonzalez

  • 1Neuroradiology Section, Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, 6565 Fannin Street, Houston, TX 77030, USA. steve_fung@post.harvard.edu

Neuroimaging Clinics of North America
|June 7, 2011
PubMed

Insights

Diffusion-weighted MRI is crucial for detecting cerebral ischemia early and defining infarct cores. Advanced techniques like diffusion tensor and kurtosis imaging offer deeper insights into tissue microstructures in stroke patients.

Area of Science:

  • Radiology and Medical Imaging
  • Neuroscience
  • Biomedical Engineering

Background:

  • Water molecule diffusion in the brain generates contrast in diffusion-weighted MRI (DW-MRI).
  • DW-MRI is the gold standard for identifying early cerebral ischemia and stroke.
  • Other advanced diffusion MRI techniques provide further microstructural tissue information.

Purpose of the Study:

  • To review the evolution and clinical applications of diffusion-weighted imaging (DWI).
  • To discuss the utility of diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI).
  • To cover the role of these MRI techniques in managing acute and chronic ischemia.

Main Methods:

  • Review of scientific literature on diffusion MRI techniques.
  • Analysis of DWI, DTI, and DKI principles and methodologies.
  • Examination of clinical case studies and research findings in ischemia.

Main Results:

  • DW-MRI reliably detects early cerebral ischemia and defines infarct core.
  • DTI and DKI provide valuable data on tissue microstructural integrity.
  • These techniques aid in differentiating stroke from mimics and assessing chronic ischemia.

Conclusions:

  • Diffusion-weighted MRI techniques are indispensable in stroke diagnosis and management.
  • DTI and DKI enhance diagnostic capabilities beyond conventional DWI.
  • Continued research will further refine the application of diffusion MRI in neurological disorders.

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