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Related Experiment Video

Updated: Jun 1, 2026

Fission Yeast as a Platform for Antibacterial Drug Screens Targeting Bacterial Cytoskeleton Proteins

Fission Yeast as a Platform for Antibacterial Drug Screens Targeting Bacterial Cytoskeleton Proteins

Published on: April 26, 2024

Form follows function -- the versatile fungal cytoskeleton.

Alexander Lichius¹, Adokiye Berepiki, Nick D Read

¹Fungal Cell Biology Group, Institute of Cell Biology, Rutherford Building, University of Edinburgh, Edinburgh EH9 3JH, UK.

|June 7, 2011

Summary

This summary is machine-generated.

The fungal cytoskeleton, composed of F-actin, microtubules, and septins, is crucial for cell shape. New live-cell imaging tools allow real-time monitoring of these components during fungal growth and development.

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Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Area of Science:

Mycology
Cell Biology
Biochemistry

Background:

The fungal cytoskeleton, comprising F-actin, microtubules, and septins, is essential for regulating fungal cell morphogenesis.
Understanding the dynamic interactions of these polymers is key to deciphering fungal growth and development.

Purpose of the Study:

To review the versatile fungal cytoskeleton.
To highlight recent insights into F-actin roles in filamentous fungi.
To discuss future research directions enabled by new experimental tools.

Main Methods:

Live-cell imaging using the Lifeact probe for F-actin.
Utilizing existing microtubule markers.
Employing fluorescently labeled septins for simultaneous monitoring.

Main Results:

Real-time dynamics of the entire fungal cytoskeleton (F-actin, microtubules, septins) can now be monitored.
Accumulating evidence suggests varied roles of higher-order cytoskeletal structures in different fungal cell types.
Cytoskeletal architecture differs significantly between yeasts, spore germlings, and hyphae.

Conclusions:

New imaging tools provide unprecedented opportunities to study fungal cytoskeleton dynamics.
Integrated roles of F-actin, microtubules, and septins are critical throughout fungal life.
Further research will elucidate the complex cytoskeletal functions in diverse fungal forms.