Event-related potentials in children with attention deficit hyperactivity disorder: an investigation using an
Magdalena Senderecka1, Anna Grabowska, Krzysztof Gerc
1Psychophysiology Laboratory, Institute of Psychology, Jagiellonian University, Cracow, Poland. magdalena.senderecka@uj.edu.pl
Insights
Children with attention deficit hyperactivity disorder combined type (ADHD-Com) show distinct brain activity differences compared to typically developing children. These electrophysiological findings suggest deficits in automatic and controlled processing, impacting attention and executive functions.
Area of Science:
- Neuroscience
- Developmental Psychology
- Clinical Psychology
Background:
- Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder.
- Understanding the electrophysiological underpinnings of ADHD is crucial for diagnosis and intervention.
- Previous research indicates potential differences in brain activity, but specific patterns require further investigation.
Purpose of the Study:
- To investigate electrophysiological brain activity differences in children with ADHD combined type (ADHD-Com) versus typically developing children.
- To utilize the auditory 2-tone oddball paradigm to assess event-related potentials (ERPs).
- To correlate ERP findings with cognitive processing deficits in ADHD.
Main Methods:
- Forty children (ages 6.9-12.3), matched for age and gender, participated.
- Participants included individuals with ADHD-Com and a control group.
- An auditory oddball task measured ERPs (P2, N2, P3 components) in response to standard and target stimuli.
Main Results:
- Task performance did not differ between ADHD and control groups.
- ADHD group exhibited enhanced P2 and reduced N2 components to oddball stimuli.
- ADHD group showed reduced P3 component to targets, particularly over the right hemisphere.
Conclusions:
- Children with ADHD-Com demonstrate altered automatic and controlled processing.
- Enhanced P2 suggests early orienting deficits.
- Reduced N2 and P3 point to impairments in stimulus discrimination, conflict monitoring, and executive functions like attention allocation.
Abstract:
The aim of the study was to investigate differences in electrophysiological brain activity between children diagnosed with attention deficit hyperactivity disorder combined type (ADHD-Com) and normally developing children, using the auditory 2-tone oddball paradigm. Forty right-handed subjects aged between 6.9 and 12.3 years participated in the present study, with 16 boys and 4 girls in each of the control and ADHD-Com groups. Children were individually age- and gender-matched. The auditory oddball task consisted of 155 standards (1 KHz, p=.66) and 80 targets (1.5 KHz, p=.34), presented randomly one at a time. Subjects were instructed to listen to the sounds and count the rare tones. Task performance in ADHD children did not differ compared to that in the control group. Event-related potentials (ERPs) elicited to target and standard stimuli were analyzed for between-group differences. The ADHD group showed enhanced P2 and reduced N2 component to both oddball stimuli, followed by reduced P3 component to attended targets compared with controls. The difference in the P3 amplitude between targets and standards was smaller in the ADHD group, particularly over the right hemisphere. These results suggest deficiencies in both automatic and controlled processing in children with ADHD. Enhanced amplitude of the P2 in ADHD children may reflect an early orienting deficit which affects later processing stages in the oddball task. Reduced amplitude of the N2 in the clinical group may be associated with stimulus discrimination impairment and inappropriate conflict monitoring. Reduced amplitude of target P3 and its asymmetrical distribution in ADHD children may reflect a deficit in higher-level executive functions, such as attention allocation and stimulus evaluation, accompanied by an impairment of global aspects of attentional processing that are under right hemisphere control.
