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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging.

Masashi Tsujimoto1, Jo Senda, Tetsuro Ishihara

  • 1Department of Neurology, Nagoya University Graduate School of Medicine, Japan.

Journal of the Neurological Sciences
|June 7, 2011
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) patients show early apathy, linked to frontal lobe degeneration. This suggests a connection between ALS and frontotemporal dementia, highlighting behavioral changes in early illness.

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Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a complex neurological disorder affecting frontotemporal functions.
  • Behavioral changes in ALS are not fully understood, necessitating further research.

Purpose of the Study:

  • To investigate behavioral changes in early-stage ALS patients.
  • To explore the relationship between brain degeneration and behavioral alterations in ALS.

Main Methods:

  • Assessed 21 ALS patients and 21 controls using the Frontal System Behavior Scale (FrSBe).
  • Employed Voxel-Based Morphometry (VBM) and Diffusion Tensor Imaging (DTI) to analyze brain structure and white matter integrity.
  • Evaluated patients prior to ALS diagnosis notification.

Main Results:

  • ALS patients exhibited significantly higher FrSBe scores compared to controls before notification.
  • Apathy scores in ALS patients showed significant changes from pre- to post-illness.
  • Apathy severity correlated with prefrontal cortex atrophy (VBM) and right frontal gyrus degeneration (DTI).

Conclusions:

  • ALS patients experience apathy early in the disease course.
  • Apathy severity is significantly associated with frontal lobe involvement in ALS.
  • Findings support a continuum between ALS and frontotemporal dementia.