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Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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Chronic Obstructive Pulmonary Disease I: Introduction

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

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Related Experiment Video

Updated: Jun 1, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Intersections between pulmonary development and disease.

Jeffrey A Whitsett¹, Hans Michael Haitchi, Yutaka Maeda

¹Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. jeff.whitsett@cchmc.org

American Journal of Respiratory and Critical Care Medicine

|June 7, 2011

Summary

Recent biology advances show lung development pathways are reactivated in lung diseases. Understanding these shared genetic mechanisms is key for treating pulmonary disorders.

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Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

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Published on: December 21, 2014

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Last Updated: Jun 1, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

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Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Area of Science:

Cellular Biology
Molecular Biology
Developmental Biology
Organogenesis
Pulmonary Medicine

Background:

Lung formation and pulmonary disease pathogenesis are complex processes.
Debate exists on whether developmental processes in lung morphogenesis are recapitulated during lung repair or in chronic lung diseases.

Purpose of the Study:

To explore the relationship between lung development and the pathogenesis of lung disorders.
To investigate the role of genetic machinery in both normal lung development and disease.

Main Methods:

Review of recent advances in cellular, molecular, and developmental biology.
Analysis of evidence linking developmental genetic pathways to lung disease pathogenesis.

Main Results:

Increasing evidence suggests shared genetic mechanisms regulate cell growth, specification, and differentiation in both normal lung development and various lung disorders.
While distinct cellular events may occur, the underlying genetic 'machinery' appears conserved.

Conclusions:

The pathogenesis of many lung disorders involves genetic pathways crucial for normal lung development.
This finding has significant implications for understanding and potentially treating pulmonary diseases by targeting developmental pathways.