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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Modulation of an n→π* interaction with α-fluoro groups

Amit Choudhary, Charles G Fry, Ronald T Raines

    ARKIVOC : Free Online Journal of Organic Chemistry
    |June 7, 2011
    PubMed
    Summary

    Fluorine substitution can tune the noncovalent n→π* interactions crucial for protein structures. Electron withdrawal by fluorine weakens the interaction, while steric bulk can overcome this effect, offering new modulation strategies.

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