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Updated: Jun 1, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Clopidogrel-associated acute generalized exanthematous pustulosis
Justin Craig Ellerbroek1, Mark G Cleveland
1Great River Medical Center, West Burlington, Iowa, USA. justin.ellerbroek@gmail.com
Cutis
|June 8, 2011
Summary
Acute generalized exanthematous pustulosis (AGEP) is a severe skin reaction. This case highlights clopidogrel as a potential cause and discusses successful desensitization for future use.
Area of Science:
- Dermatology
- Pharmacology
- Internal Medicine
Background:
- Acute generalized exanthematous pustulosis (AGEP) presents as a rapid, widespread pustular eruption.
- AGEP is often associated with fever and leukocytosis, typically resolving within 15 days.
Observation:
- An 83-year-old woman developed AGEP after coronary stent placement and clopidogrel initiation.
- Initial discontinuation of carvedilol and rosuvastatin did not resolve the patient's worsening rash, fever, and leukocytosis.
Findings:
- Biopsy-confirmed AGEP was diagnosed after excluding other causes.
- Discontinuation of clopidogrel led to rapid improvement in the patient's temperature, white blood cell count, and creatinine levels.
- The patient experienced skin desquamation and was discharged on day 20.
Implications:
- This case underscores clopidogrel as a potential trigger for drug-induced AGEP.
- Successful clopidogrel desensitization is discussed as a viable option for patients with prior cutaneous reactions.
- Understanding drug-induced AGEP is crucial for appropriate patient management and medication selection.
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