Related Experiment Video
Updated: Jun 1, 2026
11:44
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Quantitative determination of bucindolol concentration in intact gel capsules using Raman spectroscopy
T M Niemczyk1, M M Delgado-Lopez, F S Allen
1Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131.
Analytical Chemistry
|June 8, 2011
Summary
Near-infrared Raman spectroscopy offers rapid, nondestructive quality control for pharmaceuticals. This method analyzes intact capsules within blister packs, showing potential for efficient pharmaceutical analysis.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Sciences
- Spectroscopy
Background:
- Pharmaceutical quality control demands rapid, nondestructive testing methods.
- Current methods may not efficiently analyze intact dosage forms within packaging.
Purpose of the Study:
- To evaluate near-infrared Raman spectroscopy for rapid, nondestructive quality control of pharmaceutical products.
- To assess the feasibility of analyzing drug formulations in gel capsules and within blister packs.
Main Methods:
- Utilized near-infrared Raman spectroscopy for spectral data acquisition.
- Analyzed intact gel capsules and capsules within blister packs.
- Employed multivariate calibration to correlate spectral data with active ingredient concentration (bucindolol).
Main Results:
- Obtained useful spectral data directly from drug formulations in gel capsules and within blister packs.
- Achieved a calibration standard error of prediction (SEP) of 3.36 mg for bucindolol content.
- Identified sample inhomogeneity as the primary source of error.
Conclusions:
- Near-infrared Raman spectroscopy demonstrates significant potential as a rapid, nondestructive quality control method for pharmaceutical samples.
- The technique is effective for analyzing intact capsules, even inside blister packs.
- Further optimization may mitigate errors from sample inhomogeneity.
