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Updated: Jun 1, 2026
12:13
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
Nutrigenetics and prostate cancer: 2011 and beyond.
Yinan Yuan1, Lynnette R Ferguson
1Discipline of Nutrition, University of Auckland, New Zealand.
Journal of Nutrigenetics and Nutrigenomics
|June 8, 2011
Summary
Nutrients significantly influence prostate cancer risk and progression by interacting with genes. Future research should explore complex gene interactions and epigenetic changes for a comprehensive understanding.
Area of Science:
- Nutrigenetics and Cancer Epidemiology
- Molecular Oncology
Background:
- Prostate cancer exhibits familial clustering and is influenced by diet.
- Identifying key genetic risk factors for prostate cancer has been challenging.
Purpose of the Study:
- To summarize current knowledge on nutrient-gene interactions in prostate cancer risk and progression.
- To explore the role of diet in prostate cancer etiology and development.
Main Methods:
- A comprehensive literature search was conducted using MEDLINE.
- Review of hypothesis-directed candidate gene studies and genome-wide association studies (GWAS).
Main Results:
- Candidate gene studies suggest plausible but weak nutrient-gene interactions affecting carcinogenesis.
- GWAS identified novel genes potentially regulated by nutrients, impacting susceptibility and progression.
- Few genes identified by GWAS have been formally tested for dietary associations.
Conclusions:
- Future research must investigate complex genetic variations (beyond single nucleotide polymorphisms) and epigenetic modifications.
- Large international cohorts are needed to elucidate individual and combined nutrient-gene interactions within biological pathways.
- Bioinformatics and biostatistics are crucial for advancing nutrigenetic research.
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