Related Experiment Video

Updated: Jun 1, 2026

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening
05:54

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

Published on: September 5, 2018

SRC-3 has a role in cancer other than as a nuclear receptor coactivator

Gang Ma1, Yu Ren, Ke Wang

  • 1Department of Surgical Oncology, First Affiliated Hospital, Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, P. R. China.

International Journal of Biological Sciences
|June 8, 2011
PubMed

Insights

Steroid receptor coactivator-3 (SRC-3) is crucial in hormone-dependent cancers. Emerging evidence reveals SRC-3 also drives hormone-independent cancers through novel mechanisms beyond its coactivator role.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is part of the p160 family.
  • SRC-3 amplification in breast cancer (1997) spurred extensive research into its oncogenic roles.
  • Initially recognized for coactivating nuclear receptors like estrogen receptor (ER) in hormone-dependent cancers.

Purpose of the Study:

  • To review the multifaceted roles of SRC-3 in cancer.
  • To explore SRC-3 functions beyond its established role as a nuclear receptor coactivator.
  • To examine SRC-3's involvement in hormone-independent cancers.

Main Methods:

  • Literature review of in vivo and in vitro studies.
  • Analysis of clinical evidence on SRC-3 expression and cancer pathology.
  • Examination of data from SRC-3 transgenic mouse models.

Main Results:

  • SRC-3 dysregulation correlates with poor prognosis in hormone-independent cancers.
  • In vivo and in vitro studies show SRC-3 influences cancer processes independently of nuclear receptors.
  • SRC-3 transgenic models demonstrate its potential to induce tumors across various tissues.

Conclusions:

  • SRC-3's role in cancer extends beyond nuclear receptor coactivation.
  • SRC-3 is implicated in the progression of hormone-independent cancers.
  • Further investigation into non-coactivator functions of SRC-3 is warranted for therapeutic strategies.
Keywords:
Steroid receptor coactivator-3apoptosiscell cycleinvasion and metastasismice modeltumorigenesis

More Related Videos

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts11:19

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Published on: October 9, 2016

Three-Dimensional (3D) Tumor Spheroid Invasion Assay12:19

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Published on: May 1, 2015

Related Concept Videos

Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...