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Investigating the purpose of prelamin A processing

Brandon Sj Davies1, Catherine Coffinier, Shao H Yang

  • 1Department of Medicine, University of California, Los Angeles, USA.

Nucleus (Austin, Tex.)
|June 8, 2011
PubMed
Summary

The processing of prelamin A into mature lamin A is essential for heart health. Exclusive production of nonfarnesylated prelamin A in mice causes cardiomyopathy, highlighting the importance of prelamin A processing.

Keywords:
cardiomyopathyprelamin Aprogeriaprotein farnesylationrestrictive dermopathy

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