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Assessment of pituitary adenoma volumetric change using longitudinal MR image registration
Geir Andre Ringstad1, Kyrre Eeg Emblem, Dominic Holland
1Clinic for Imaging and Intervention, Oslo University Hospital-Rikshospitalet, Sognsvannsvn 20, Oslo, Norway. geir.ringstad@rikshospitalet.no
Introduction:
Change detection is a crucial factor in monitoring of slowly evolving pathologies. The objective of the study was to test a semi-automatic method applied on longitudinal MRI monitoring of volume change in pituitary macroadenomas.
Methods:
The proposed method is based on a visual comparison of geometrically corrected, co-registered, intensity-normalized contrast-enhanced (CE) 3D GRE T1-weighted images. Qualitative volume changes based on this applied method were compared with experts' readings of conventional pre- and post-CE 2D T1-weighted images. Magnetic resonance (MR) imaging was performed two to four times in 13 patients with a total combination of 29 time points.
Results:
Compared to conventional 2D MR readings, a diagnosis of tumor growth (yes/no) was changed in 5 of 13 patients (38%) at 9 of the 29 combinations of time points (31%) using the 3D-based semi-automatic method. With manual tumor tracings as reference, McNemar's test showed a significant difference between the two methods.
Conclusion:
Visual comparison of geometrically corrected, intensity-normalized, and affine-aligned longitudinal 3D images may enable more accurate assessment of qualitative volumetric change in pituitary adenomas than conventional reading of 2D images.
