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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
The Pituitary Gland01:17

The Pituitary Gland

The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...

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Related Experiment Video

Updated: Jun 1, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

MicroRNAs in the human pituitary.

Milani Sivapragasam1, Fabio Rotondo, Ricardo V Lloyd

  • 1Department of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, ON M5B1W8, Canada.

Endocrine Pathology
|June 8, 2011
PubMed
Summary

MicroRNAs (miRNAs) are small RNAs regulating genes. Aberrant miRNA expression in the pituitary is linked to neoplasia and pituitary adenomas, offering insights into tumorigenesis.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • MicroRNAs (miRNAs) are key post-transcriptional gene regulators.
  • Pituitary pathology, particularly adenomas, shows links to abnormal miRNA expression.
  • miRNAs are implicated in controlling cell proliferation and tumorigenesis.

Purpose of the Study:

  • To review the significance of miRNAs in pituitary pathology.
  • To explore the role of miRNAs in pituitary adenoma development and progression.

Main Methods:

  • Literature review of studies on miRNAs in pituitary pathology.
  • Analysis of research connecting miRNA expression to clinicopathological features of pituitary adenomas.
  • Examination of miRNA target genes and their involvement in biological pathways.

Main Results:

  • Aberrant miRNA expression is a hallmark of pituitary neoplasia.
  • Specific miRNA dysregulation correlates with clinicopathological features of pituitary adenomas.
  • Altered expression of miRNA target genes provides insights into pituitary tumorigenesis.

Conclusions:

  • MicroRNAs play a critical role in pituitary pathology.
  • Understanding miRNA regulation is crucial for comprehending pituitary adenoma development.
  • miRNAs represent potential therapeutic targets in pituitary cancer.